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KMID : 0363620080290020081
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Journal of Korean Oriental Medicine
2008 Volume.29 No. 2 p.81 ~ p.95
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Effect of Whitmania pigra whitman on the Allergic Inflammatory Response
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Lee Ju-Yong
Kim Eun-Gyung
Oh Hyun-A
Lee Hyun-Sam
Sohn Young-Joo
Jung Hyuk-Sang
Kim Yoon-Bum
Park Seong-Kyu
Sohn Nak-Won
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Abstract
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Objectives: Whitmania pigra whitman (WP) has been used in herbal medicine to treat various conditions, such as
eczema, skin burns and frostbites in herbal medicine. The purpose of this study is was to investigate the effect of WP on anti-allergy mechanism.
Methods: To clarify the mechanism, the effect of WP on vascular permeability of rat cutaneous tissue and histamine and cytokines (IL-6, IL-8, TNF-α) released from mast cells were observed.
Results: The results were 1. the pretreatment with WP significantly decreased the compound 48/80-induced degranulation and histamine release from RPMC 2. WP did not inhibit the anti-DNP IgE-induced increment of vascular permeability of rat cutaneous tissue 3. WP significantly reduced the PMA plus A23187-induced increment of expression of IL-6, IL-8, and TNF-α in HMC-1 cells.
Conclusions: The present study providesevidence that WP acid inhibits mast cell-derived inflammatory allergic
reactions by blocking histamine release and pro-inflammatory cytokine expression, and suggest the mechanisms of
action. Furthermore, in vivo and in vitro anti-allergic effect of WP suggests a possible therapeutic application of this agent in inflammatory allergic diseases.
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KEYWORD
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Whitmania pigra whitman, HMC-1 cells, histamine, passive cutaneous anaphylaxis (PCA), cytokine
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